This article explores the history of the Alexander Ecker Collection and situates it within the larger trajectory of global collecting of human remains during the nineteenth and early twentieth centuries. This is then linked to the specific context of the genocide in then German South West Africa (1904–8), with the central figure of Eugen Fischer. The later trajectory of the collection leads up to the current issues of restitution. The Freiburg case is instructive since it raises issues about the possibilities and limitations of provenance research. At the same time, the actual restitution of fourteen human remains in 2014 occurred in a way that sparked serious conflict in Namibia which is still on-going four years later. In closing, exigencies as well as pressing needs in connection with the repatriation and (where possible) rehumanisation of human remains are discussed.